Exposure to high-molecular-weight polyvinyl chloride alters bacterial diversity in the gut microbiota of the Wistar rat - Biblioteka Cyfrowa Politechniki Koszalińskiej

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Exposure to high-molecular-weight polyvinyl chloride alters bacterial diversity in the gut microbiota of the Wistar rat

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Title: Exposure to high-molecular-weight polyvinyl chloride alters bacterial diversity in the gut microbiota of the Wistar rat

Creator:

Pekmezekmek, Ayper Boga ; Emre, Mustafa ; Tunc, Erdal ; Kalay, Betül ; Kocahan, Sayad ; Emre, Nesrin ; Emre, Toygar

Date:

Type:

artykuł w czasopiśmie

Alternative title:

Wpływ polichlorku winylu o dużej masie cząsteczkowej na zmianę różnorodności bakterii w mikrobiomie jelitowym szczura Wistar

Description:

g as a vehicle for toxins to reach organisms after ingestion. The "most microbiome" comprises all the microorganisms present in our bodies as a whole because it has a big surface area and provides nutrient-rich components for the digestive system's germs. In this investigation, metagenome analysis was used to determine the impact of long-term administration of High-Molecular Weight-Polyvinyl Chloride microplastics to young Wistar rats on the gut microbiota. Forty adult rats in total were employed, with 15 first-group and 15 second-group experimental groups and 10 controls. Pellets made specifically for feeding rats are produced. Following the procedure, the rats were anaesthetised with ketamine and xylasine before being dissected. Due to the small number of samples, alpha diversity in the gut metagenome study did not demonstrate statistically significant variations, but it did illustrate differences in bacterial diversity and density. In particular, it has been discovered that bacterial diversity is higher in experimental groups. According to the control groups, in the assay groups, the intestinal microbiome, dominated by Escherichia coli, Shigella, and Lactobacillus, was assessed as an increase in metabolic pathways related to microplastic exposure and pathogenicity in general. The findings demonstrate the necessity for extreme caution in the manufacture and use of plastics that pose a risk to the welfare of living things.

Place of publishing:

Publisher:

Politechnika Koszalińska

Identifier:

oai:dlibra.tu.koszalin.pl:2101

Language:

Is part of:

Rocznik Ochrona Środowiska. Vol. 26, s. 393-402

Rights:

Biblioteka Politechniki Koszalińskiej

Access rights:

License:

Creative Commons BY-SA 4.0

Subject and keywords:

HMW-PVC intestine krona metagenome microbiota

Object collections:

Last modified:

Dec 23, 2025

In our library since:

Dec 23, 2025

Number of object content hits:

2

All available object's versions:

https://dlibra.tu.koszalin.pl/publication/2111

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Edition name	Date
2024, Pekmezekmek, Ayper Boga, Exposure to high-molecular-weight polyvinyl chloride alters bacterial diversity in the gut microbiota of the Wistar rat	Dec 23, 2025

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Citation style:

Chicago

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